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Retatrutide is the first triple agonist, a single molecule designed to activate three metabolic receptors simultaneously: GLP-1: Activates appetite suppression and insulin regulation

Lancet (1983) 1(8337):13301.10.1016/S0140-6736(83)92437-6 113 SarrMGBillingtonCJBrancatisanoRBrancatisanoAToouliJKowLet alThe EMPOWER study: randomized, prospective, double-blind, multicenter trial of vagal blockade to induce weight loss in morbid obesity

A rapid dissociation rate is also required to allow ligands to leave the receptor timeously after activation, to avoid internalization and ultimately maintain the quantity of the incretin receptors in the body